Types of Medication

Children and adults with Dravet Syndrome typically need to be taking a combination of medications to help control or reduce seizures. It is always important to remember that medication regimes remain very individual to the patient.

As with all medications, it is very important to comply with all the instructions provided when administering medications to your child, especially dosing and course completion. We suggest you speak to your child’s doctor if you have any concerns over their medication and it is essential that you speak to your medical team before altering any medications. 

Individuals with Dravet Syndrome can be very susceptible to the slightest change so all medication changes must be done in consultation with a medical professional.

Treatments currently available for Dravet Syndrome focus on controlling or minimising seizures in order to reduce their impact on development and injuries. Anti-epileptic drugs are used, but these are not always effective. Types of medication might include:

• Sodium valproate: Also known as Epilim, this is an anticonvulsant used in the treatment of epilepsy. The intravenous formulations (i.e. directly into a vein) are used in emergency scenarios.
• Clobazam: A benzodiazepine drug approved for use with other treatments, for patients with epilepsy who have not responded to or who are resistant to first-line drugs.
• Stiripentol: Is added to sodium valproate and clobazam for treating people with Dravet Syndrome whose seizures are not adequately controlled with valproate and clobazam alone. In addition, it may be used to treat refractory childhood epilepsy in conjunction with carbamazepine. Stiripentol is currently only licenced for use in Dravet Syndrome.
• Cannabidiol: Also known as Epidyolex, cannibidiol oral solution is a plant-derived cannabis-based medicine. It is newly available via the NHS as a possible treatment for seizures associated with Dravet Syndrome in conjunction with clobazam for people aged 2 years and over. For more information see our 'New and Emerging Treatments' page.
• Topiramate: An anticonvulsant drug used to treat epilepsy in children and adults.
• Levetiracetam: An anticonvulsant medication used to treat epilepsy; it has been approved for treatment as a single medication in the case of partial seizures, or as an add on medication for partial, myoclonic and tonic clonic seizures.
• Bromides: This is one of the older antiepileptic medications. It is not prescribed much in the UK but is often the first-line medication for Dravet Syndrome in Germany and Japan. It is used by some UK Dravet Syndrome specialists.

Medications that should NOT be used with Dravet Syndrome

Medications which can increase or prolong seizures in some individuals with Dravet Syndrome include: 

Carbamazepine, lamotrigine, and phenytoin (although phenytoin can increase seizures if used as a daily maintenance medication, it can be useful when used intravenously as an emergency treatment).